Source review: September 22, 2026. Virginia law does not use one undifferentiated “drug DUI” rule. Virginia Code § 18.2-266 separates impairment involving a self-administered drug, combined influence involving alcohol and drugs, and a blood-concentration branch limited to four named substances.
This statewide guide explains those statutory branches, why the source or administration of a substance can matter under clause (iii), and how Virginia law treats a reported drug result outside clause (v). It does not decide guilt, admissibility, scientific significance, medical safety, or the result of an individual case.
Virginia Code § 18.2-266 describes several ways a DUI charge may be prosecuted. Three clauses are especially relevant when the allegation involves medication or another drug:
The section also states that a charge alleging a violation of § 18.2-266 may support a conviction under any of its five clauses. The charging document, offense date, evidence, instructions, and judgment therefore matter more than an informal label such as “prescription DUI” or “drug DUI.”
The current text of § 18.2-266 does not contain an exception that turns only on whether a substance was lawfully prescribed. A prescription, label, pharmacy record, treatment record, and evidence about who administered a substance may still be important parts of the factual record. None of those facts, standing alone, establishes guilt or a defense.
Clause (iii) requires attention to the statute’s word “self-administered.” The Supreme Court of Virginia has addressed that requirement in two fact-specific opinions. Those decisions do not create a blanket rule for every prescription, emergency-room treatment, clinic visit, or medication record.
In Jackson v. Commonwealth, 274 Va. 630 (2007), the Supreme Court held that clause (iii) requires the narcotic drug or other intoxicant or drug to be self-administered. The record showed that a nurse administered the identified medication in a hospital. The Court reversed and dismissed the conviction because the statutory self-administration requirement was not met on that record.
In Lambert v. Commonwealth, 298 Va. 510 (2020), the Supreme Court reaffirmed that self-administration is an element under clause (iii) and distinguished Jackson. The Court held that the evidence and reasonable inferences in Lambert were sufficient to support the jury’s finding of self-administration, including evidence concerning voluntary participation in a methadone-treatment program and the broader record described in the opinion.
The contrast between the opinions is a reason to identify the actual source and administration evidence, not a basis for predicting the result of another case. Whether evidence is relevant, admissible, credible, or sufficient remains a record-specific legal question.
Clause (v) of § 18.2-266 names four substances and exact blood-concentration values:
These values should not be attached to a different substance, rounded, or converted into a numerical rule for marijuana, an opioid, a benzodiazepine, a sleep medication, or another unlisted drug.
Clause (v) itself defines a concentration-based branch of § 18.2-266. Separately, Virginia Code § 18.2-269(A)(4) states that, in the prosecutions identified in subsection A, a qualifying chemical analysis at or above the same four values gives rise to a rebuttable presumption that the accused was under the influence of drugs to a degree that impaired the ability to drive or operate safely.
The word “rebuttable” matters. So do the prosecution identified in the charging record, the testing route, the foundation for the result, and the other evidence. This guide does not decide how the presumption applies, whether it was rebutted, or whether any result is admissible or sufficient.
Virginia Code § 18.2-268.10(A) states that, except in a prosecution under clause (v), a test result indicating the presence of a drug other than alcohol is admissible only if other competent evidence has been presented to relate the drug’s presence to impairment of the accused’s ability to drive or operate safely. Subsection D directs the factfinder, for clauses (ii), (iii), and (iv), to determine guilt or innocence from all the evidence concerning the accused’s condition at the time of the alleged offense.
Those provisions identify a legal evidence framework. They do not establish what a particular concentration means, whether a metabolite reflects impairment, when a substance was taken, how substances interacted, or whether expert testimony is required in every case. This candidate makes none of those scientific or categorical claims.
A useful legal review starts by identifying the statutory theory and preserving the complete record. Depending on what exists, relevant categories may include:
This list does not say that every item is relevant, admissible, complete, or available in every matter. Preserve complete, unedited records. Do not upload medication lists, diagnoses, treatment records, toxicology reports, or confidential case details through an unapproved public form or automated assistant.
This guide does not interpret dose, onset, peak effect, half-life, elimination, detection window, laboratory cutoff, parent drug, metabolite, “therapeutic” or “toxic” range, drug interaction, tolerance, diagnosis, or whether any amount caused impairment. It also does not answer when a person can safely drive after taking medication. Those issues may require the actual report and qualified medical or scientific review.
It also does not address Drug Recognition Expert protocols, credentials, or reliability. Ownership and primary-source requirements for that subject remain unresolved.
The legal significance of a reported drug result is different from whether a blood specimen was lawfully and reliably collected, documented, sealed, transferred, received, retained, or made available for independent analysis. Those specimen-provenance questions require a separate source and record review. This guide does not summarize them.
This page is limited to the drug and prescription-medication charge-and-evidence question. It does not replace the broader Hampton Roads DUI guide, the guide to a first DUI offense in Virginia, the separate Virginia DUI process guide, the guide to breath testing and refusal, or the guide to license suspension, VASAP, restricted driving, and ignition interlock.
Field-sobriety-test administration, traffic-stop and body-camera issues, blood-sample provenance, crash or injury charges, civil claims, penalties, and locality-specific representation questions also remain outside this page’s job.
Virginia statutes and the treatment of opinions can change. The precise charge, statutory clause, source of a substance, chemical-analysis record, other evidence, and procedural posture may change the analysis. Review the current official sources and obtain legal advice tied to the actual documents and alleged facts.
This page provides general legal information, not legal or medical advice for a particular matter. It does not create an attorney-client relationship or promise a result, fee, response time, availability, or acceptance of representation.

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